Original article

BioMedicine

, 4:6

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Metabolic Abnormality and Sleep Disturbance are Associated with Clinical Severity of Patients with Schizophrenia

  • Chung-Chieh HungAffiliated withGraduate Institute of Clinical Medical Science, China Medical UniversityDepartment of Psychiatry, China Medical University Hospital
  • , Chin-Chih LiaoAffiliated withDepartment of Psychiatry, China Medical University Hospital
  • , Po-Lun WuAffiliated withGraduate Institute of Clinical Medical Science, China Medical UniversityDepartment of Psychiatry, China Medical University Hospital
  • , Shin-Da LeeAffiliated withGraduate Institute of Rehabilitation Science, China Medical UniversityDepartment of Physical Therapy, China Medical University Hospital
  • , Hsien-Yuan LaneAffiliated withGraduate Institute of Clinical Medical Science, China Medical UniversityDepartment of Psychiatry, China Medical University HospitalInstitute of Clinical Medical Science, College of Medicine, China Medical University Email author 

Abstract

Schizophrenic patients suffer from more metabolic or sleep problems. Little is known about risk factors. We recruited 17 patients with chronic schizophrenia from the rehabilitation center in a medical center in Taiwan and measured their demographic data, cognitive performance, and physical fitness, metabolic profiles and sleep parameters. They were divided into two groups according to clinical severity, then compared in terms of metabolic and sleep parameters.

Those with more severe symptomatology had more metabolic abnormality and shorter slow wave sleep (SWS). Our findings suggest clinical symptoms as linked with heavier body weight, wider neck circumference, elevated blood pressure, and shorter SWS. Further studies are warranted to confirm the preliminary finding and to elucidate the underlying mechanism

Keywords

Schizophrenia Metabolic syndrome Sleep disturbance Slow wave sleep Body weight Neck circumference