Article

BioMedicine

, 4:10

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Coronary artery aneurysms occurrence risk analysis between Kawasaki disease and LRP1B gene in Taiwanese children

  • Ying-Ju LinAffiliated withDepartment of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Xiang LiuAffiliated withNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda
  • , Jeng-Sheng ChangAffiliated withDepartment of Pediatrics, China Medical University Hospital
  • , Wen- Kuei ChienAffiliated withBiostatistics Center, Taipei Medical UniversityBiostatistics Center, China Medical University
  • , Jin-Hua ChenAffiliated withBiostatistics Center, Taipei Medical UniversityBiostatistics Center, China Medical University
  • , Hsinyi TsangAffiliated withNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda
  • , Chien-Hui HungAffiliated withGraduate Institute of Clinical Medical Science, Chang-Gung University
  • , Ting-Hsu LinAffiliated withDepartment of Medical Research, China Medical University Hospital
  • , Shao-Mei HuangAffiliated withDepartment of Medical Research, China Medical University Hospital
    • , Chiu-Chu LiaoAffiliated withDepartment of Medical Research, China Medical University Hospital
    • , Cheng-Wen LinAffiliated withDepartment of Medical Laboratory Science and Biotechnology, China Medical University
    • , Tsung-Jung HoAffiliated withSchool of Chinese Medicine, China Medical UniversityDivision of Chinese Medicine, China Medical University Beigang HospitalDivision of Chinese Medicine, Tainan Municipal An-Nan Hospital -China Medical UniversityDepartment of Medical Research, China Medical University Hospital Email author 
    • , Fuu-Jen TsaiAffiliated withDepartment of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical UniversityDepartment of Biotechnology, Asia University Email author 

Abstract

Background: Kawasaki disease (KD) is an acute and systemic vasculitis. Its complications in coronary artery aneurysms (CAA) make KD one of the leading causes of acquired cardiovascular diseases in childhood. Low density lipoprotein receptor-related protein 1B (LRP1B) is abundantly expressed in the medial layer of coronary arteries and involved in endothelium inflammations.

Purpose: We aimed to identify the role of LRP1B in CAA formation during KD progression.

Methods: we investigated genetic variations in LRP1B in a Taiwanese cohort of 258 KD patients (83 with CAA and 175 without CAA complications). We used univariate and multivariate regression analyses to identify the associations between LRP1B genetic variations and KD patients.

Results: CAA formation in KD was significantly associated with the LRP1B (rs6707826) genetic variant (p = 0.007). By using multivariate regression analysis, significant correlations were observed between KD with CAA complications and the presence of the TT+TG genotypes for the LRP1B rs6707826 single-nucleotide polymorphism (full model: odds ratio = 2.82; 95% CI = 1.33–5.78).

Conclusion: Our results suggest that genetic polymorphism of LRP1B gene may be used as a genetic marker for the diagnosis and prognosis of the CAA formation in KD and contribute to genetic profiling studies for personalized medicine.

Keywords:

KD LRP1B Single-nucleotide polymorphism CAA