, 4:12

First online:

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Auricularia polytricha aqueous extract supplementation decreases hepatic lipid accumulation and improves antioxidative status in animal model of nonalcoholic fatty liver

  • Wan-Chun ChiuAffiliated withSchool of Nutrition and Health Sciences, Taipei Medical University
  • , Hsu-Hui YangAffiliated withCouncil of Agriculture, Executive Yuan, Fengshan Tropical Horticultural Experimental Branch
  • , Shu-Chi ChiangAffiliated withSchool of Nutrition and Health Sciences, Taipei Medical University
  • , Yu-Xuan ChouAffiliated withDepartment of Nutrition, China Medical University
  • , Hui-Ting YangAffiliated withDepartment of Nutrition, China Medical University Email author 


Background: Amelioration effect of Auricularia polytricha water extract (AP) on hepatic injury in an animal model of NAFLD was investigated.

Methods: Forty six-week-old Wistar rats were housed and thirty-two fed ten percent lard high-fat diet to induce NAFLD. After eight weeks of induction, animals were divided into five groups of eight rats each: normal control, high-fat diet, RN (reversion to a normal diet), 1× AP (normal diet plus 0.75% AP, w/w), and 2×AP (normal diet plus 1.5% AP). Animals were sacrificed four weeks later.

Results: Rats receiving either 0.75% or 1.5% AP exhibited effective interruption of NAFLD progression, as evidenced by decreased lipid accumulation and elevated antioxidative status.

Histological examination proved AP anti-inflammatory function and lower level of related markers for tumor necrosis factor-α and interleukin-6. Besides abundant polysaccharides against lipid accumulation, AP had a specific high level of phenolic compounds and tannins thus may be a potent anti-inflammatory and antioxidative agent.

Conclusion: Findings suggest that under normal diet recovery, AP supplement may represent novel, protective material against NAFLD by attenuating inflammatory response, oxidative stress and lipid deposition.


Auricularia polytricha Non-alcoholic fatty liver disease Two-hit theory