Review article

BioMedicine

, 4:23

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Molecular targets for anti-oxidative protection of green tea polyphenols against myocardial ischemic injury

  • Shih-Rong HsiehAffiliated withDepartment of Cardiovascular Surgery, Taichung Veterans General Hospital
  • , Wei-Chen ChengAffiliated withInstitute of Bioinformatics and Structural Biology, National Tsing Hua University
  • , Yi-Min SuAffiliated withDepartment of Life Sciences, National Chung-Hsing University
  • , Chun-Hwei ChiuAffiliated withDepartment of Life Sciences, National Chung-Hsing University
  • , Ying-Ming LiouAffiliated withDepartment of Life Sciences, National Chung-Hsing UniversityRong Hsing Research Center for Translational Medicine, National Chung Hsing University Email author 

Abstract

Ischemic heart disease is the leading cause of death worldwide. An improved understanding of the mechanisms involved in myocardial injury would allow intervention downstream in the pathway where certain drugs including natural products could be efficiently applied to target the end effectors of the cell death pathway. Green tea polyphenols (GTPs) have potent anti-oxidative capabilities, which may account for their beneficial effects in preventing oxidative stress associated with ischemia injury. Although studies have provided convincing evidence to support the protective effects of GTPs in cardiovascular system, the potential end effectors that mediate cardiac protection are only beginning to be addressed. Proteomics analyses widely used to identify the protein targets for many cardiovascular diseases have advanced the discovery of the signaling mechanism for GTPs-mediated cardio-protection. This review focuses on putative triggers, mediators, and end effectors for the GTPs-mediated cardio-protection signaling pathways engaged in myocardial ischemia crisis, allowing a promising natural product to be used for ameliorating oxidative stress associated with ischemic heart diseases.

Keywords

Cardio-protection Green tea polyphenols (GTPs) Ischemic heart disease Oxidative stress Proteomics