Review article

BioMedicine

, 4:25

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Mass spectrometry-based proteomics in Chest Medicine, Gerontology, and Nephrology: subgroups omics for personalized medicine

  • Shih-Yi LinAffiliated withInstitute of Clinical Medical Science, China Medical University College of MedicineDepartment of Internal Medicine, China Medical University HospitalDivision of Nephrology and Kidney Institute, China Medical University Hospital
  • , Wu-Huei HsuAffiliated withInstitute of Clinical Medical Science, China Medical University College of MedicineDepartment of Internal Medicine, China Medical University HospitalDivision of Pulmonary and Critical Care Medicine, China Medical University Hospital and China Medical University
  • , Cheng-Chieh LinAffiliated withInstitute of Clinical Medical Science, China Medical University College of MedicineDepartment of Family Medicine, China Medical University HospitalSchool of Medicine, College of Medicine China Medical University
  • , Chao-Jung ChenAffiliated withGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical UniversityProteomics Core Laboratory, Department of Medical Research, China Medical University Hospital Email author 

Abstract

Mass spectrometry (MS) is currently the most promising tool for studying proteomics to investigate largescale proteins in a specific proteome. Emerging MS-based proteomics is widely applied to decipher complex proteome for discovering potential biomarkers. Given its growing usage in clinical medicine for biomarker discovery to predict, diagnose and confer prognosis, MS-based proteomics can benefit study of personalized medicine. In this review we introduce some fundamental MS theory and MS-based quantitative proteomic approaches as well as several representative clinical MS-based proteomics issues in Chest Medicine, Gerontology, and Nephrology.

Keywords

Mass spectrometry; Personalized medicine; Proteomics; Chest Medicine; Nephrology; Gerontology