Original article

BioMedicine

, 4:26

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia suppress the tumorigenicity of head and neck cancer cells in vivo

  • Ching-Wen ChangAffiliated withInstitute of Oral Biology, National Yang-Ming University
  • , Yu-Syuan ChenAffiliated withInstitute of Oral Biology, National Yang-Ming University
  • , Chien-Chih ChenAffiliated withDepartment of Biotechnology, Hungkuang University
  • , Chin-Chu ChenAffiliated withGrape King Inc
  • , Sen-Je SheuAffiliated withGrape King Inc
  • , Ting-wei LinAffiliated withGrape King Inc
  • , Te-Chang LeeAffiliated withInstitute of Biomedical Sciences, Academia Sinica
  • , Jeng-Fan LoAffiliated withInstitute of Oral Biology, National Yang-Ming UniversityGraduate Institute of Chinese Medical Science and Institute of Medical Science, China Medical UniversityGenome Research Center, National Yang-Ming UniversityDepartment of Dentistry, Taipei Veterans General Hospital

Abstract

Head and neck cancer (HNC) is one of the most common forms of cancer in Taiwan. In addition, head and neck cancer cells (HNCs) are highly tumorigenic and resistant to conventional therapy. Therefore, development of new therapeutic regimens that are adjuvant to conventional treatments would benefit future head and neck cancer therapy. In this study, we found that the lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia inhibited the tumor growth of HNCs by xenograft assay in vivo. Moreover, administration of lyophilized particles or ethanolic extracts to nude mice did not cause significant side effects. Our study revealed that the Antrodia cinnamomea mycelia extract (ACME) efficiently inhibited the tumorigenicity of HNCs without causing organ failure. Furthermore, it showed that ACME may work as a novel drug candidate for alternative treatments for head and neck cancer.

Keywords:

Antrodia cinnamomea; Head and neck cancer