Case report


, 6:6

First online:

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Solitary renal metastasis of esophageal squamous cell carcinoma mimicking primary renal neoplasm – A case report and literature review

  • Kai-Po ChangAffiliated withDepartment of Pathology, China Medical University Hospital
  • , Chi-Ping HuangAffiliated withDepartment of Urology, China Medical University Hospital
  • , Han ChangAffiliated withDepartment of Pathology, China Medical University HospitalDepartment of Pathology, College of Medicine, China Medical University Hospital Email author 


Solitary renal metastasis of esophageal cancer is rare clinically, with only 14 cases being reported in the literature. The authors here report a case of a 53-year-old man with a metachronous hypopharyngeal and esophageal squamous cell carcinoma who developed a solitary renal metastasis after complete chemoradiotherapy for esophageal cancer, and subsequently received a left nephrectomy. The metastatic esophageal cancer was indistinguishable from primary renal neoplasm in the computed tomography but showed the histopathologic characteristic of esophageal cancer in directly invading the renal artery, and the tumor spreading in the kidney. The patient died of pneumonia two months after diagnosis. Among the previous 14 reported cases, 12 occurred in Asians, and their overall survival time ranges from two months to nine years after nephrectomy, either with or without adjuvant chemotherapy. Accordingly, a solitary renal mass in patients with a history of esophageal cancer is warranted to differentiate metastatic esophageal cancer from primary renal neoplasm, and a reliable therapy needs to be planned early for improving the patient’s chance of survival.


Solitary renal metastasis Esophageal cancer Squamous cell carcinoma