Article

BioMedicine

, 6:7

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan

  • Shih-Yin ChenAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Yuan-Man HsuAffiliated withDepartment of Biological Science and Technology, China Medical University
  • , Ying-Ju LinAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Yu-Chuen HuangAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Chao-Jung ChenAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Wei-De LinAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Wen-Lin LiaoAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Yng-Tay ChenAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
  • , Wei-Yong LinAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
    • , Yu-Huei LiuAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical University
    • , Jai-Sing YangAffiliated withGenetics Center, Department of Medical Research, China Medical University Hospital
    • , Jinn-Chyuan SheuAffiliated withInstitute of Biomedical Sciences, National Sun Yat-sen University
    • , Fuu-Jen TsaiAffiliated withGenetics Center, Department of Medical Research, China Medical University HospitalSchool of Chinese Medicine, China Medical UniversityDepartment of Medical Genetics, China Medical University Hospital Email author 

Abstract

Diabetic retinopathy (DR) is one of the most feared complications of diabetes and is a leading cause of acquired blindness in working adults. The prevalence of undiagnosed diabetes in Taiwan is about 4%, and the annual incidence of T2D (Type 2 Diabetes) in Taiwan is 1.8% following the 1985 WHO criteria. Multiple mechanisms have been shown in T2DR with some signaling pathways, including the polyol pathway, PKC pathway, AGEs pathway, and MAPK pathway. However, the cause of vision loss in diabetic retinopathy is complex and remains incompletely understood. Herein, we try to fully understand the new concepts regarding hyperglycemia-induced biochemical pathways contributing to DR pathophysiology. Our work may be able to provide new strategies for the prevention and treatment of diabetic vascular complications.

Keywords:

Diabetic retinopathy (DR) Retina Inflammation Oxidative stress Vascular damage