Article

BioMedicine

, 6:11

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Prevalence and factors of elevated alanine aminotransferase in central Taiwan – a retrospective study

  • Hsien-Feng LinAffiliated withSchool of Chinese Medicine, China Medical UniversityCollege of Medicine, China Medical University
  • , Shih-Wei LaiAffiliated withCollege of Medicine, China Medical UniversityDepartment of Family Medicine, China Medical University Hospital
  • , Wen-Yuan LinAffiliated withCollege of Medicine, China Medical UniversityDepartment of Family Medicine, China Medical University Hospital
  • , Chiu-Shong LiuAffiliated withCollege of Medicine, China Medical UniversityDepartment of Family Medicine, China Medical University Hospital
  • , Cheng-Chieh LinAffiliated withCollege of Medicine, China Medical UniversityDepartment of Family Medicine, China Medical University Hospital
  • , Ching-Mei ChangAffiliated withDepartment of Nursing, Tungs’ Taichung Metro Habor Hospital

Abstract

Background

The aims of this study were to assess the prevalence of elevated alanine aminotransferase (ALT) and explore its related factors in Central Taiwan.

Methods

The study employed a retrospective design. The study selected a sample of 5,550 subjects between the years 2000 to 2004. The indivduals undergoing health examinations in a medical center in Central Taiwan were enrolled as subjects for this research. The patients’ demographics, smoking and drinking habits, laboratory findings, and abdominal ultrasound results were collected and analyzed. Correlations between variables were analyzed using SPSS/ PC Windows for frequency distribution, t-test, Chi-square test, and multivariate logistic regression.

Results

There were 3103 men (55.9%) and 2447 women (44.1%). The mean age was 49.4 ± 12.3 years (age range of 20-87). The overall prevalence of elevated ALT was 17.1%, with a significant gender difference (23.2% in men vs. 9.4% in women, P < .0001). The multivariate logistic regression analysis showed that the factors significantly related to elevated ALT were central obesity, hypertriglyceridemia, and anti-HCV positive in men and women.

Conclusions

Central obesity, hypertriglyceridemia, and anti-HCV positive are factors predominantly related to elevated ALT in men and women.

Keywords:

ALT Hepatitis B Hepatitis C Hypertriglyceridemia Obesity