Review article

BioMedicine

, 6:19

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Treating hepatocellular carcinoma with 90Y-bearing microspheres: a review

  • Te-Chun HsiehAffiliated withDepartment of Nuclear Medicine and PET Center, China Medical University HospitalDepartment of Biomedical Imaging and Radiological Science, China Medical University
  • , Yu-Chin WuAffiliated withDepartment of Nuclear Medicine, National Taiwan University Hospital Hsin-Chu Branch Email author 
  • , Shung-Shung SunAffiliated withDepartment of Nuclear Medicine and PET Center, China Medical University HospitalDepartment of Biomedical Imaging and Radiological Science, China Medical University
  • , Kuo-Yang YenAffiliated withDepartment of Nuclear Medicine and PET Center, China Medical University HospitalDepartment of Biomedical Imaging and Radiological Science, China Medical University
  • , Chia-Hung KaoAffiliated withDepartment of Nuclear Medicine and PET Center, China Medical University HospitalSchool of Medicine, China Medical University Email author 

Abstract

Hepatocellular carcinoma (HCC) is a disease usually diagnosed in its advanced-stage, and is frequently not amenable to curative surgical treatment. Also, HCC is resistant to chemotherapy and less vulnerable to radiation therapy compared to normal hepatic parenchyma. Both of these facts render the efficacy of adjuvant and palliative treatments problematic. Selective internal radiation therapy (SIRT) with 90Y-bearing microspheres is characterized by preferentially delivering substantially high doses of radiation to a liver tumor dose simultaneously limiting the damage to its non-tumorous cells, providing an opportunity for effective local tumor control and even tumor regression therapy. The current article reviews the specific characters, dosimetry, possible applications, and special considerations toward the pre-existing radiation therapy of 90Y microsphere SIRT in treating HCC.

Keywords:

Hepatocellular carcinoma 90Y microspheres Selective internal radiation therapy 99mTc macroaggregated albumin Transarterial chemoembolization External beam radiation therapy Radiation lobectomy