Review article


, 6:20

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Magnesium deficiency and oxidative stress: an update

  • Anastasia A. ZheltovaAffiliated withDepartment of Pharmacology, Volgograd State Medical UniversityDepartment of Immunology and Allergology, Volgograd State Medical University
  • , Maria V. KharitonovaAffiliated withDepartment of Pharmacology, Volgograd State Medical UniversityInstitute of Pharmacy, Department of Pharmacology and Toxicology, University of Innsbruck
  • , Igor N. IezhitsaAffiliated withDepartment of Pharmacology, Volgograd State Medical UniversityCentre for Neuroscience Research (NeuRon), Faculty of Medicine, Universiti Teknologi MARA (UiTM)RIG “Molecular Pharmacology and Advanced Therapeutics”, Pharmaceutical & Life Sciences (PLS) Communities of Research (CoRe),, Universiti Teknologi MARAFaculty of Medicine, Sungai Buloh Campus, Jalan Hospital, Universiti Teknologi MARA Email author 
  • , Alexander A. SpasovAffiliated withDepartment of Pharmacology, Volgograd State Medical University


Magnesium deficiency (MgD) has been shown to impact numerous biological processes at the cellular and molecular levels. In the present review, we discuss the relationship between MgD and oxidative stress (OS). MgD is accompanied by increased levels of OS markers such as lipid, protein and DNA oxidative modification products. Additionally, a relationship was detected between MgD and a weakened antioxidant defence. Different mechanisms associated with MgD are involved in the development and maintenance of OS. These mechanisms include systemic reactions such as inflammation and endothelial dysfunction, as well as changes at the cellular level, such as mitochondrial dysfunction and excessive fatty acid production.


Magnesium Magnesium deficiency Oxidative stress Antioxidants Reactive oxygen species Lipid peroxidation