Review

Biomedical Research and Therapy

, 2:2

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Immune-O-Toxins as the magic bullet for therapeutic purposes

  • Suchita SrivastavaAffiliated withYeast Epigenetic Regulation Laboratory, CSIR-Institute of Microbial Technology
  • , Suaib LuqmanAffiliated withMolecular Bioprospection Department of Biotechnology Division, Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Institute of Medicinal and Aromatic Plants Email author 

Abstract

Immunotoxins are chimeric molecules embodied with a protein toxin and a ligand which is either a growth factor or an antibody. The ligand part of the immunotoxin recognizes and binds to an antigen of the target cell, allowing the internalization of the toxin-moiety and permitting its drift to the cytoplasm where it can destroy the cell. Target specificity of the chimeric protein is determined via the binding attributes of the chosen antibody. Predominantly, immunotoxins are purposefully constructed to slay cancer cells as part of novel treatment approach. In addition they are also used for various autoimmune, viral and other infectious diseases. With the advent of biotechnology, recombinant immunotoxins have been created and are clinically tested to target malignant cells. Our article summarizes foremost progress in the development of immunotoxin based therapeutics and presents a comprehensive portrayal of the immunotoxin generation.

Keywords

Immunologic conconjugates Immunotoxin Monoclonal antibodies Toxin based therapy