Original Research

Biomedical Research and Therapy

, 2:19

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Toxoplasmosis Gondii Infection and Diabetes Mellitus Type 2 Treated by Using Autologous Peripheral Blood Stem Cells a Unique Case Report of a Caucasian 83 Year Old Lady

  • Ciro GargiuloAffiliated withDivision of Internal Medicine, The Human Medicine International Clinic Email author 
  • , Van Hung PhamAffiliated withMolecular Diagnostics Department, Nam Khoa-Biotek Laboratory
  • , Kieu C.D. NguyenAffiliated withDivision of Internal Medicine, The Human Medicine International Clinic
  • , Ngan Duong KimAffiliated withDivision of Internal Medicine, The Human Medicine International Clinic
  • , Thinh Nguyen VanAffiliated withDivision of Internal Medicine, The Human Medicine International Clinic
  • , An Luu TuanAffiliated withDivision of Internal Medicine, The Human Medicine International Clinic
  • , Kenji AbeAffiliated withDepartment of Pathology, National Institute of Infectious Diseases
  • , Melvin ShiffmanAffiliated withSection of Surgery, Newport Specialty Hospital

Abstract

Introduction: Toxoplasma gondii is an intracellular protozoan responsible for up to one-third of the world’s population infestation. Diabetes is one of the most silent and threatening disease of the modern time it is constantly increasing in both industrialized and developing countries. This is a case of clinically importance for two reason, firstly it will help clinicians save a broad differential diagnosis when attending to evaluate analogous cases and secondly, it may confirm the role of autologous peripheral blood stem cells (PB-SCs) in enhancing auto-immune response against parasitic infection and in regulating insulin uptake in diabetes mellitus type 2 (DM2). Case presentation: We present a unique case of 83- year-old woman from Argentina presenting with a widespread erythema and urticaria for 5 months and DM2 as underlying condition. She was initially diagnosed with unspecific skin auto-immune disorder. By the time of visit she was complaining of constant diarrhea-constipation and general mental and physical fatigue. Conclusion: This case illustrates that toxoplasmosis can present with just simple disseminated and generalized skin erythema with severe itching and, thus can be confused with similar infectious disease such as Epstein-Barr virus (EBV), cytomegalovirus, cat scratch disease or leishmaniasis. The report emphasizes the need of correct diagnostic procedure in confusing cases, and may help to increase the awareness about the identification of this disease. This case may open to the possibility of a different approach and methodology in treatment T gondii and DM2 through the use of PB-SCs.

Keywords

Toxoplasma gondii Human Peripheral Blood Stem cells NK cells CD3 CD4 CD8