Original Research

Biomedical Research and Therapy

, 3:14

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

In vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer for total hip replacement

  • Ngoc Bich VuAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University
  • , Nhung Hai TruongAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University
  • , Long Thanh DangAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University
  • , Lan Thi PhiAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University
  • , Nga Thi-Thu HoAffiliated withNational key Laboratory of Digital Control and System Engineering, Vietnam National University
  • , Tuan Ngoc PhamAffiliated withNational key Laboratory of Digital Control and System Engineering, Vietnam National University
  • , Trinh Phuong PhanAffiliated withCenter for Technology Development and Equipment Saigon
  • , Phuc Van PhamAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University Email author 

Abstract

Introductions

Joint replacements have considerably improved the quality of life of patients with damaged joints. Over the past 30 years, there has been much effort and investigations in ways to repair damages in joints, including knee and hip joints. Materials for joint production have also been developed. Many improvements have been made in the joint replacement materials to increase their biocompatibility and longevity. This study is aimed at evaluating the in vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer used in total hip replacements.

Methods

Ti-6Al-4V titanium alloy and UHMWPE polymer were carefully washed with sterile distilled water then autoclaved. The materials were used directly or indirectly to evaluate pyrogens, endotoxins, animal cell cytotoxicity, gene mutation, animal cell transformation, DNA synthesis, immunogenicity, histology reactions, and immune response. All assays were performed according to ISO10993 guidelines.

Results

The results showed that Ti- 6Al-4V titanium alloy and Chirulen 1020 UHMWPE polymer satisfied all criteria for implantable materials.

Keywords

Ti-6Al-4V titanium alloy Chirulen 1020 polymer biocompatibility total hip replacement