Review

Biomedical Research and Therapy

, 3:21

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Is the neutrophil extracellular trap-driven microvascular inflammation essential for diabetes vasculopathy?

  • Alexander BerezinAffiliated withConsultant of Therapeutic Unit, Internal Medicine Department, State Medical University for Zaporozhye Email author 

Abstract

The neutrophil extracellular traps (NETs) are defined as an extensive web consisting decondensed chromatin, which is released from activated neutrophils, as well as cytotoxic proteins, histones and microbicidal proteases that cause tissue damage. NETs contribute to endothelial damage, inflammation, thrombosis, platelet aggregation, ischemia, that are essential players in the pathobiology of diabetic complications. The objective of the review is to highlight the possible role of NETosis in early diabetes-related vasculopathy beyond cardiovascular complications. Although the clinical significance of NETosis in diabetes beyond early atherosclerosis and cardiovascular complications is not still clear, there is limited data with respect to useful to use biological markers of NETosis aimed early stratification of the diabetics at risk of disease progression. Furthermore, several inductors of NETosis might be a target for novel pharmacological approaches to delay advance in diabetes and prevent diabetes-related vasculopathy.

Keywords:

Diabetes mellitus neutrophil extracellular traps vasculopathy wound healing microvascular inflammation