Review

Biomedical Research and Therapy

, 3:22

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Concise Review: 3D cell culture systems for anticancer drug screening

  • Huyen Thi-Lam NguyenAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University
  • , Sinh Truong NguyenAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University
  • , Phuc Van PhamAffiliated withLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University Email author 

Abstract

Three-dimensional (3D) cultures are becoming increasingly popular due to their ability to mimic tissuelike structures more effectively than monolayer cultures. In cancer research, the natural tumor characteristics and architecture are more closely mimicked by 3D cell models. Thus, 3D cell cultures are more promising and suitable models, particularly for in vitro drug screening to predict in vivo efficacy. Different methods have been developed to create 3D cell culture systems for research application. This review will introduce and discuss 3D cell culture methods most popularly used in drug screening. The potential applications of these systems in anticancer drug screening will also be discussed.

Keywords:

3D culture anticancer drug screening mimic tissue-like structure