Review

Biomedical Research and Therapy

, 3:31

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Resurrection of neurodegenerative diseases via stem cells

  • Siranjeevi NagarajAffiliated withIndian Institute of Technology Email author 

Abstract

Neurodegenerative diseases (NDDs) are complex disorders that degenerates central nervous system. To this end, we have achieved only palliative treatments and their success is limited. Emerging studies suggest stem cells could be an alternative to recover lost neural network. Transplanting stem cells for replacing damaged neurons is a pivotal step in cell replacement therapies. In this article, NDDs and their pathology, current methods of combating NDDs and potentiality of stem cells in treating NDDs have been reviewed briefly. In addition to this , technical issues that hamper clinical applications of stem cells in creating cellular models and grafted cells for neuron resurrection have been discussed.

Keywords:

Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Frontotemporal lobar degeneration Amyotrophic lateral sclerosis Induced Pluripotent cells