Original Research

Biomedical Research and Therapy

, 3:50

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Potential evaluation of central nervous system anti-depressant activity of Cleome rutidosperma in mice

  • Fahima Faroque ArchiAffiliated withDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South University
  • , Salma IslamAffiliated withDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South University
  • , Md. Ahsan Habib Khan BabuAffiliated withDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South University
  • , Ahsan UllahAffiliated withDepartment of Pharmacy, International Islamic University Chittagong
  • , Shofiul AzamAffiliated withDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South UniversityDepartment of Pharmacy, International Islamic University Chittagong Email author 
  • , Amin ChowdhuryAffiliated withDepartment of Pharmacy, International Islamic University Chittagong
  • , Mahfujur RahmanAffiliated withDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South University
  • , Md. Salimul KarimAffiliated withDepartment of Pharmacy, Northern University Bangladesh
  • , Sukdeb GoswamiAffiliated withDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South University

Abstract

Introduction:

This investigation was carried out to analyze the central nervous system (CNS) depressant effect of the plant Cleome rutidosperma extract, after it was found to have been used by the local people in the Philippine for that purpose.

Methods:

In this study presented below, the CNS depressant effects of the extract was evaluated in in vivo mice models; using the standard procedures of Open field, Hole cross and Thiopental sodium induced sleeping time tests.

Results:

Using two test extracts at a concentration of 100 and 200 mg/kg, it was seen that the extracts showed significant (p< 0.01) dose dependent suppression of motor activity in both open field and hole cross test, 4.67 ± 0.68** and 3.00 ± 0.45**, respectively at 200 mg/kg. It also showed significant (p< 0.01) decrease in the time for the onset of sleep (5.00 ± 0.45 at 200 mg/kg); and an increase in sleeping duration (70.20 ± 0.66 at 200 mg/kg), when compared with the positive control Thiopental sodium.

Conclusion:

Overall, the study demonstrates that the extracts used, showed promising CNS depressant effect. Further study needs to be carried out on the extract to isolate the active constituent, so that it can be assessed for therapeutic use.

Keywords

CNS anxiolytic hole cross test thiopental motor neuron activity