Article

GSTF Journal of Chemical Sciences (JChem)

, 1:4

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Anticancer, Antibacterial, Antifungal Activities for Hybrid Probes of Aromatic Amine and Barbituric Acid

  • Bhaveshkumar D. DhorajiyaAffiliated withDepartment of Applied Chemistry, S.V. National Institute of Technology
  • , Bharatkumar Z. DholakiyaAffiliated withDepartment of Applied Chemistry, S.V. National Institute of Technology Email author 
  • , Nimisha SinghAffiliated withDepartment of Applied Chemistry, S.V. National Institute of Technology

Abstract

Cancer and microbes today remains one of the most deadly diseases in the world. In search of novel anticancer and antimicrobial probes, a series of newly hybrid molecules synthesized by combining the structural features of aromatic amines and barbituric acid, using the concept of green chemistry. This approach was accomplished efficiently using the aqueous medium to give the corresponding products in a high yield. The newly synthesized compounds were characterized by spectral analysis FT-IR, 1H NMR, 13C-NMR, HMBC, MASS and Elemental Analysis. Evaluations of these molecules have been carried out using four human cancer cell lines against Doxorubicin as a standard drug. Moreover all the synthesized barbiturates probes were evaluated for their antimicrobial activity against five bacterial strains and four fungal strains. Taken together, this study has led to the development of a convenient, a highly yielded and an environmentally friendly synthetic method of highly promising leads for anticancer and antimicrobial compounds.

Graphical Abstract-

https://static-content.springer.com/image/art%3A10.7603%2Fs40837-014-0004-6/MediaObjects/40837_2014_4_Fig1_HTML.jpg

Keyword

Green Chemistry N-Formylation Knoevenagel Condensation Anticancer Antimicrobial activies